High affinity hemoglobin and Parkinson's disease.
Identifieur interne : 000A47 ( Main/Exploration ); précédent : 000A46; suivant : 000A48High affinity hemoglobin and Parkinson's disease.
Auteurs : Jeffrey Graham [Canada] ; Douglas Hobson [Canada] ; Arjuna Ponnampalam [Canada]Source :
- Medical hypotheses [ 1532-2777 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : 2,3-Diphosphoglycerate.
- chemical , metabolism : Dopamine, Hemoglobins, Reactive Oxygen Species.
- blood : Parkinson Disease.
- metabolism : Dopaminergic Neurons, Neurons, Substantia Nigra.
- Blood Gas Analysis, Humans, Mutation, Oxidative Stress.
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra (SN) region of the midbrain. Oxidative damage in this region has been shown to play an important role in the pathogenesis of this disease. Human neurons have been discovered to contain hemoglobin, with an increased concentration seen in the neurons of the SN. High affinity hemoglobin is a clinical entity resulting from mutations that create a functional increase in the binding of hemoglobin to oxygen and an inability to efficiently unload it to tissues. This can result in a number of metabolic compensatory changes, including an elevation in circulating hemoglobin and an increase in the molecule 2,3-diphosphoglycerate (2,3-DPG). Population based studies have revealed that patients with PD have elevated hemoglobin as well as 2,3-DPG levels. Based on these observations, we hypothesize that the oxidative damage seen in PD is related to an underlying high affinity hemoglobin subtype.
DOI: 10.1016/j.mehy.2014.10.016
PubMed: 25468785
Affiliations:
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Electronic address: aponnampalam@cancercare.mb.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology, University of Manitoba, Winnipeg, Manitoba</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25468785</idno><idno type="pmid">25468785</idno><idno type="doi">10.1016/j.mehy.2014.10.016</idno><idno type="wicri:Area/PubMed/Corpus">000629</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000629</idno><idno type="wicri:Area/PubMed/Curation">000629</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000629</idno><idno type="wicri:Area/PubMed/Checkpoint">000629</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000629</idno><idno type="wicri:Area/Ncbi/Merge">001989</idno><idno type="wicri:Area/Ncbi/Curation">001989</idno><idno type="wicri:Area/Ncbi/Checkpoint">001989</idno><idno type="wicri:Area/Main/Merge">000A50</idno><idno type="wicri:Area/Main/Curation">000A47</idno><idno type="wicri:Area/Main/Exploration">000A47</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">High affinity hemoglobin and Parkinson's disease.</title><author><name sortKey="Graham, Jeffrey" sort="Graham, Jeffrey" uniqKey="Graham J" first="Jeffrey" last="Graham">Jeffrey Graham</name><affiliation wicri:level="4"><nlm:affiliation>Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Hobson, Douglas" sort="Hobson, Douglas" uniqKey="Hobson D" first="Douglas" last="Hobson">Douglas Hobson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Ponnampalam, Arjuna" sort="Ponnampalam, Arjuna" uniqKey="Ponnampalam A" first="Arjuna" last="Ponnampalam">Arjuna Ponnampalam</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address: aponnampalam@cancercare.mb.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology, University of Manitoba, Winnipeg, Manitoba</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author></analytic><series><title level="j">Medical hypotheses</title><idno type="eISSN">1532-2777</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>2,3-Diphosphoglycerate (blood)</term><term>Blood Gas Analysis</term><term>Dopamine (metabolism)</term><term>Dopaminergic Neurons (metabolism)</term><term>Hemoglobins (metabolism)</term><term>Humans</term><term>Mutation</term><term>Neurons (metabolism)</term><term>Oxidative Stress</term><term>Parkinson Disease (blood)</term><term>Reactive Oxygen Species (metabolism)</term><term>Substantia Nigra (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>2,3-Diphosphoglycerate</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term><term>Hemoglobins</term><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Dopaminergic Neurons</term><term>Neurons</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Blood Gas Analysis</term><term>Humans</term><term>Mutation</term><term>Oxidative Stress</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra (SN) region of the midbrain. Oxidative damage in this region has been shown to play an important role in the pathogenesis of this disease. Human neurons have been discovered to contain hemoglobin, with an increased concentration seen in the neurons of the SN. High affinity hemoglobin is a clinical entity resulting from mutations that create a functional increase in the binding of hemoglobin to oxygen and an inability to efficiently unload it to tissues. This can result in a number of metabolic compensatory changes, including an elevation in circulating hemoglobin and an increase in the molecule 2,3-diphosphoglycerate (2,3-DPG). Population based studies have revealed that patients with PD have elevated hemoglobin as well as 2,3-DPG levels. Based on these observations, we hypothesize that the oxidative damage seen in PD is related to an underlying high affinity hemoglobin subtype.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Manitoba</li></region><settlement><li>Winnipeg</li></settlement><orgName><li>Université du Manitoba</li></orgName></list><tree><country name="Canada"><region name="Manitoba"><name sortKey="Graham, Jeffrey" sort="Graham, Jeffrey" uniqKey="Graham J" first="Jeffrey" last="Graham">Jeffrey Graham</name></region><name sortKey="Hobson, Douglas" sort="Hobson, Douglas" uniqKey="Hobson D" first="Douglas" last="Hobson">Douglas Hobson</name><name sortKey="Ponnampalam, Arjuna" sort="Ponnampalam, Arjuna" uniqKey="Ponnampalam A" first="Arjuna" last="Ponnampalam">Arjuna Ponnampalam</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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